2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid, CAS 503309-11-3, is a fluorinated arylboronic acid used as a building block in organic synthesis. Its boronic acid group can participate in Suzuki–Miyaura cross-coupling reactions, allowing chemists to form carbon–carbon bonds and introduce the substituted aryl group into a target molecule. The structure contains both a fluoro substituent and a trifluoromethyl group, which may be useful when designing compounds with specific electronic or structural features. At Maison Chemical, we help B2B buyers assess product documentation, specifications, packaging, and supply requirements before placing an inquiry.
This compound is an aromatic boronic acid: a phenyl ring bearing a boronic acid group, written as –B(OH)2. The ring also carries a fluorine atom at position 2 and a trifluoromethyl group, –CF3, at position 4 when numbered from the boronic acid substituent. These groups define the compound’s substitution pattern and distinguish it from other fluorinated phenylboronic acids.
The compound has the molecular formula C7H5BF4O2 and a calculated molar mass of about 207.92 g/mol. The formula represents four fluorine atoms in total: one attached directly to the aromatic ring and three within the trifluoromethyl group. These are identity-level details; buyers should use the supplier’s current product specification and certificate of analysis to confirm the supplied material’s release criteria.
In synthesis, the position of each substituent can influence how a building block fits into a target structure and how the aryl group behaves in a reaction. The fluorine and trifluoromethyl groups are part of the molecule being transferred during an aryl coupling; they are not interchangeable with the boronic acid functionality. Their presence may be relevant to medicinal chemistry, agrochemical research, or materials-oriented discovery, but suitability depends on the specific target and experimental results.
The principal role of this compound is to provide a substituted aryl group in carbon–carbon bond-forming chemistry. A common context is Suzuki–Miyaura coupling, in which an organoboron reagent couples with an organic electrophile under an appropriate catalyst and reaction conditions. The exact reaction setup depends on the coupling partner, catalyst system, solvent, base, temperature, and substrate compatibility.
It is a starting material or intermediate, not a finished pharmaceutical ingredient or a ready-made performance additive. A chemist typically selects it when a project requires the specific 2-fluoro-4-trifluoromethylphenyl motif. Reaction yield, selectivity, and product quality must be established for the individual process rather than assumed from the compound’s identity alone.
Research teams may evaluate this building block while preparing candidate molecules or analog libraries that contain a fluorinated aromatic group. The fluorine and trifluoromethyl substituents provide defined structural features for a design strategy, but their effect on biological activity, metabolism, or physical properties is molecule-dependent. The building block itself should not be described as having a therapeutic effect.
In agrochemical discovery and other specialty synthesis programs, chemists may use the compound to access substituted aromatic intermediates for further evaluation. Its relevance depends on the intended molecular structure and the team’s route design. Commercial buyers should therefore share the intended use category and project scale with suppliers when seeking a suitable grade or quantity.
Process chemists may assess an arylboronic acid during route scouting or synthesis development. Before advancing to a larger campaign, they generally need to evaluate compatibility, impurity control, work-up, and downstream purification on their own process. A supplier can provide product and logistics information, but cannot replace route-specific laboratory assessment.
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Product availability, grade, and packaging can vary by supplier and order. Do not assume that a catalog listing defines every lot’s release limits or that different suppliers use identical analytical methods. Ask for the current specification and lot-specific documentation when those details are important to your application.
| Item to Confirm | Why It Matters | Buyer Question |
|---|---|---|
| Identity and CAS number | Confirms the requested chemical and substitution pattern. | Does the documentation identify CAS 503309-11-3 and the requested name? |
| Purity or assay | Supports evaluation against the buyer’s process requirements. | What release limit and analytical method apply to the available lot? |
| Analytical documents | Provides lot-specific information for incoming material review. | Can a certificate of analysis or other available quality document be provided? |
| Packaging and quantity | Helps align the order with handling, storage, and project scale. | What pack sizes and order quantities can be quoted? |
| Storage and transport guidance | Supports appropriate handling after dispatch and receipt. | Which conditions are stated on the current label and safety documentation? |
Start by confirming that the supplier can identify the material unambiguously by both chemical name and CAS number. Then review the specification, available analytical documentation, packaging options, and the supplier’s process for addressing quality questions. For regulated or tightly controlled projects, confirm in advance whether the supplier’s documentation and change-notification practices meet your internal requirements.
Request a quote that states the offered quantity, price basis, packaging, estimated lead time, and shipping terms. These details are order-specific and should be confirmed in writing rather than inferred from a general product page. If your project has a delivery deadline, ask whether the quoted schedule is based on available stock or on a new production or procurement requirement.
Also discuss the intended application and any constraints on material handling or documentation. The supplier may be able to clarify available options, but buyers remain responsible for reviewing the safety data sheet, local import requirements, and their own internal qualification criteria. Avoid making a purchase decision from the chemical name alone when lot acceptance criteria are important.
At Maison Chemical, we support B2B inquiries for 2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid CAS 503309-11-3 by helping buyers clarify product identity, required quantity, documentation needs, packaging preferences, and destination. We can review the requested specification against the information available for the offered material and discuss quotation and delivery details. Availability, lead time, and documentation should be confirmed for each inquiry.
To help us respond efficiently, include the CAS number, target quantity, destination country, required purity or specification, and any document or packaging requirements. If you are screening the material for a particular synthesis, you may also share relevant handling or process constraints. We can then assess the inquiry and provide the applicable supply information without implying that a particular grade or delivery schedule is guaranteed before confirmation.
2-Fluoro-4-(trifluoroMethyl)phenylboronic Acid is a defined fluorinated arylboronic acid used as a synthetic building block, especially where a route calls for the corresponding substituted aryl group in coupling chemistry. Its identity is associated with CAS 503309-11-3, formula C7H5BF4O2, and a calculated molar mass of approximately 207.92 g/mol. Whether it is appropriate for a particular project depends on the target structure, reaction design, and the buyer’s material requirements.
For a practical next step, confirm the required specification and quantity, then request current documentation, packaging, availability, and a written quotation. Contact Maison Chemical with your destination and purchasing requirements to discuss sourcing for your B2B project.
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